
Head into any pharmacy, and also you’ll encounter an alphabet soup of nutritional vitamins and minerals. However when you’re not cautious about which dietary supplements you incorporate in your weight-reduction plan — and which vitamins you’re pairing in your physique — you may be losing your cash.
“Vitamins have synergistic results; they don’t work in isolation,” explains Dr. Joseph Mercola, Board Licensed Household Drugs Osteopathic Doctor (DO) and Creator of Your Information to Mobile Well being. “Most want cofactors or different vitamins to unlock their full potential.”
Fats-soluble nutritional vitamins like D, A, Ok, or E, for instance, are absorbed to a far decrease diploma when taken with out fats. With out vitamin K2, vitamin D would don’t know the place to go. And a few vitamins, like zinc, can truly intrude along with your absorption of others, like copper.
This doesn’t imply that vitamins are fully ineffective when you don’t pair them. “However some are considerably much less efficient with out the suitable cofactors,” explains Mercola. “When you’re not aware of nutrient interactions, you may be consuming loads of a sure vitamin or mineral with out reaping the total advantages.”
Fortunately, lengthy earlier than fashionable science might clue us into precisely why, cuisines all over the world have taken benefit of sure nutrient pairings to craft scrumptious meals that ship nutritional vitamins and minerals in bioavailable pairs and teams. Listed below are 5 significantly scrumptious nutrient pairs to get pleasure from.
1. Curcumin and Piperine

Buttery, golden-yellow turmeric lends a recent but earthy taste to a bunch of Indian dishes. It’s additionally wealthy in curcumin, a polyphenol that has been clinically confirmed to assist handle inflammatory circumstances like metabolic syndrome, arthritis, and even muscle soreness1.
However as a 2017 analysis evaluation in Meals explains, curcumin shouldn’t be very bioavailable: It’s poorly absorbed, and it will get metabolized and eradicated far too quickly to supply many advantages by itself. Fortunately, when taken with piperine, the foremost energetic element of black pepper, the bioavailability of curcumin is elevated by a whopping 2000%.
Dishes That includes This Pairing
It’s unsurprising that turmeric is so usually paired with pepper, like in a cozy vegan coconut dal or this anti-inflammatory turmeric tonic. You can even reap the advantages of this pairing with a fast and simple turmeric roasted hen breast recipe or a facet of comforting mashed candy potatoes with turmeric and pepper.
2. Calcium and Vitamin D
Calcium is crucial for wholesome bone formation, but it surely’s nothing with out its buddy Vitamin D. “You’ll be able to eat all of the calcium-rich meals on the earth, however with out sufficient vitamin D, your physique received’t be capable to take up and put it to use successfully,” explains Mercola.
Vitamin D helps enhance absorption of calcium in your intestines, and it additionally helps regulate calcium ranges in your blood — which is why the calcium and vitamin D relationship is so necessary. “This makes certain it reaches your bones, the place it’s truly wanted,” says Mercola, “as an alternative of ending up in your arteries and different problematic locations.”
Sources of Vitamin D

Egg yolks are an incredible supply of vitamin D, particularly once they’re pasture-raised. A 2020 examine in Traits in Meals Science & Expertise discovered that feeding hens extra vitamin D3 and exposing them to UBV might considerably improve the vitamin D content material of their eggs2.
Fatty fish are additionally the most effective sources of vitamin D on the market, with only one 3.5-ounce portion of farmed Atlantic salmon masking 2/3 of your beneficial every day consumption. Nature clearly knew what it was doing — salmon can also be a wonderful supply of calcium. You’ll be able to additional improve your calcium consumption and absorption by pairing your fatty fish with meals like sesame seeds, beans, lentils, and leafy greens like spinach and collard greens.
Dishes That includes This Pairing
To reap the advantages of this pairing, dig right into a baked salmon dinner with tahini dressing or get pleasure from these straightforward paleo egg muffins with spinach.
3. Zinc and Copper
Zinc is an important mineral that helps promote immune perform and wound therapeutic. It facilitates DNA synthesis and over 300 enzymatic reactions, together with ones that support in metabolism, digestion, and nerve perform. Dave Asprey, 4x NY Occasions Bestselling Creator of Closely Meditated, Well being Science and Biotech Entrepreneur and “The Father of Biohacking,’ notes that an excessive amount of zinc can truly result in a deficiency in one other important mineral: copper.
“When you’re not getting sufficient copper, you may expertise a low intercourse drive, mind fog, much less resilience, extreme urination and stress,” he says. “A deficiency in copper additionally contributes to grey hair and osteoporosis.” To keep away from a copper deficiency, specialists suggest a zinc complement be taken alongside copper3.
Dishes That includes This Pairing

Some meals, like oysters, are wealthy in each zinc and copper. However when you’re already taking a zinc complement, select copper sources which are much less wealthy in zinc, like shiitake mushrooms and leafy greens, to make sure you’re truly getting sufficient of the mineral. A one-bowl shiitake and kale ramen recipe is simply the ticket. And end with just a few items of darkish chocolate — simply 25 grams may give you half your beneficial every day consumption of copper4.
4. B Complicated Nutritional vitamins
What are B nutritional vitamins? The various class of water-soluble B nutritional vitamins contains B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B7 (niacin), B9 (folate), and B12 (cobalamins). These nutritional vitamins, Mercola explains, “work synergistically with one another. For instance, vitamin B12 and vitamin B6 have synergistic results for mind well being.”
Usually present in excessive focus in animal-derived meals like meat, eggs, and dairy, B nutritional vitamins may also be present in leafy greens, legumes, and entire grains. B12 particularly is troublesome to seek out in plant sources. When you’ll discover it in some fermented vegetable merchandise, mushrooms, and seaweeds, the bioavailability of those sources remains to be not understood5.
Dishes That includes This Pairing
A vitamin B powerhouse of a meal may see paleo coconut-crusted salmon paired with brown rice and a spinach salad. Vegetarians might skip the salmon in favor of a hearty shakshuka, however vegans will seemingly must complement their weight-reduction plan with B nutritional vitamins to make sure they’re getting sufficient.
5. Nutritional vitamins A, D, E, and Ok
Nutritional vitamins A, D, E, and Ok are likely to work synergistically, Asprey explains, and it’s not simply because they’re all fat-soluble.
“Vitamin D helps you take up calcium, and vitamin K2 tells your physique the place to place the calcium — in your bones and enamel as an alternative of in your delicate tissues,” he says. “When you take vitamin D with out K2 you threat the calcium going into your arteries and delicate tissues, inflicting calcification, and growing cardiovascular threat.”
Particularly, vitamin K2 and vitamin D3 ought to at all times be taken collectively for correct vitamin D efficacy. Vitamin K2 is a type of vitamin Ok present in animal meals and fermented meals, and vitamin D3 is a very powerful D vitamin for people.
In the meantime, Nutritional vitamins A and E “work as highly effective antioxidants to forestall lipid oxidation and DNA injury,” Asprey explains.
What Are Fats-Soluble Nutritional vitamins?
Fats-soluble nutritional vitamins get saved within the physique within the liver, fatty tissue, and muscle tissue. In contrast to water-soluble nutritional vitamins, that are dissolved in water and don’t get saved within the physique, fat-soluble nutritional vitamins are absorbed extra simply once they’re consumed with dietary fats.
Dishes That includes This Pairing
Whereas there isn’t a single meals that features all 4 nutritional vitamins A, D, E, and Ok, there are a lot of meals with a number of. For instance, darkish leafy greens embody nutritional vitamins E and Ok, whereas avocados embody nutritional vitamins A, E, and Ok. Fatty fish are the most effective meals sources of vitamin D3, vitamin A, and vitamin E, whereas vitamin K2 is current in fermented meals like natto and sauerkraut. It’s no shock that so many cultures all over the world pair these meals, from the fish-and-sauerkraut choucroute de la mer standard in Alsace to the basic Japanese breakfast of salmon and natto.
Add Some Magnesium to the Combine

Magnesium is one other important aspect to assist your physique take up these nutritional vitamins, explains Mercola. “With out sufficient magnesium,” he says, “your physique can’t activate vitamin D.” When you take vitamin D, K2, and magnesium collectively, “the required dose of vitamin D to achieve sufficiency decreases by 244%,” he explains. Taking magnesium with nutritional vitamins could make all of the distinction in your well being.
However that is simpler mentioned than performed. It sometimes requires extra than simply reaching for a sq. of magnesium-rich darkish chocolate. Whereas Mercola typically recommends getting vitamins from entire meals, he says magnesium is “a uncommon exception.”
“Almost everyone seems to be poor,” he says, “and getting sufficient from weight-reduction plan alone might be difficult for a number of causes.” He cites soil depletion as “a serious concern,” with manufacturing facility farming stripping magnesium from the soil and downgrading once-reliable plant-based sources of the mineral. “This implies even when you eat a whole-food, plant-rich weight-reduction plan, you should still fall in need of the beneficial 400 mg every day consumption.”
“What’s extra, a few of the richest sources of magnesium — nuts and seeds — are additionally excessive in omega-6 fat like linoleic acid,” provides Mercola. “Given the widespread consumption of vegetable oils, most individuals are already getting an excessive amount of linoleic acid, which drives irritation and mitochondrial dysfunction. So, limiting these meals whereas nonetheless making an attempt to satisfy your magnesium wants is troublesome.”
For that reason, he recommends supplementing your weight-reduction plan with magnesium within the type of easy-to-absorb magnesium glycinate and magnesium malate.
Be Cautious of Antinutrients
Soil depletion isn’t the one factor to remember when constructing a weight-reduction plan wealthy in important nutritional vitamins and minerals. Sure pure compounds present in plant-based meals are generally known as “antinutrients” in sure well being and wellness circles, as a result of they have an inclination to bind to minerals and make them tougher to soak up.
An extra of phytic acid, discovered in lots of nuts, seeds, and grains, prevents full absorption of iron, zinc, calcium, and magnesium. Oxalates, current in meals like spinach, candy potatoes, almonds, beets, raspberries, and kale, can bind to calcium, forming what Mercola characterizes as “razor sharp crystals that deposit themselves in your delicate tissues.”
Whereas antinutrients “should not inherently dangerous,” says Mercola, “they’ll intrude along with your physique’s capability to soak up and use vitamins via a number of completely different mechanisms, together with binding and chelating, inhibiting digestive enzymes, interfering with nutrient transporters, lowering transit time via your digestive system, and by forming insoluble complexes.”
To assist reap the advantages of those meals to the fullest, he recommends soaking, sprouting, fermenting, or cooking these meals to assist break down antinutrients and improve their dietary worth.
Sources:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5664031/
- https://www.sciencedirect.com/science/article/abs/pii/S0924224420304799
- https://www.mountsinai.org/health-library/complement/zinc
- https://www.clinicalnutritionjournal.com/article/S0261-5614(11)00215-9/summary
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5788147/